Now is the time for the US to heed the European signal for the first time, to pull out all the stops. Promote primary vaccination and boosters like there’s no tomorrow. Aggressively counter the pervasive misinformation and disinformation. Accelerate and expand the vaccine mandates that unfortunately became necessary and have been proven effective, and mass distribute medical quality masks and rapid home testing kits at no cost. Soon enough potent pills (Molnupiravar and Paxlovid) that take down the Sars-CoV-2 virus will get authorized and should also be made widely available to help prevent hospitalizations and deaths. Otherwise, we will probably face a fifth wave. Now is not the time for happy talk, but to instead show we can persevere, run this marathon, make it to the finish line. We can acknowledge and accept endemicity – that a low level of Covid will remain in the background, but that is not >75,000 new cases a day. Instead of succumbing to yet another major rise in cases and their sequelae, this is a chance for America to finally rise to the occasion, showing an ability to lead and execute.